Unwanted side effects of sedating antihistamines Wife sex chat
Where as Quetiapine has potent antagonizing effects on Histamine H1, but also possesses antimuscarinic actions at M1 and M3.On top of that, it antagonizes Dopamine, Serotonin and Epinephrine.*Note: some of the ones listed as antagonists might possibly be inverse agonists. I have tried diphenhydramine, promethazine, and seroquel.Hydroxyzine - antagonist at the following receptors: α1-adrenergic (IC50 = 94n M) α2-adrenergic (IC50 = 271n M) D1 (IC50 = 1268n M) D2 (IC50 = 329n M) D3 (unspecified) D4 (unspecified) H1 (IC50 = 30n M) 5-HT1A (IC50 = 717n M) 5-HT2A (IC50 = 148n M) 5-HT2C (unspecified) 5-HT7 (unspecified) m ACh receptor (IC50 = α1-adrenergic (Ki = 608 n M? Out of those, seroquel was by far the most sedating, with promethazine coming in second.Most people's problem with antihistamines for sleep is they take too high a dose, assuming more is better. And when tolerance builds, taking more is not going to help because then you get more of the other stuff like anticholinergic effects.Tolerance to sedation from antihistamines can build very rapidly. Yep, as I said in my first post some antihistamines have additional mechanisms of action that may add to the sedation.
Even seroquel at tolerance-level dosing gave me very uncomfortable nightmarish RLS/insomnial hellacious torture that I would never wish to endure ever again.I can't tell if the sedative properties of certain antihistamines results from their H1 antagonism or if it's because of their cross effect with antagonizing the adrenergic receptors.Are all H1 antagonists innately sedating or is it just the first generation ones?If it wasn't for its appetite enhancement, I'd call mirt the perfect AD for my needs.(Until I took it, I had clinical depression and struggled to sleep).